Sleep and meal timing influence food intake and its hormonal regulation in healthy adults with overweight/obesity (2024)

Table of Contents
Abstract Background: Methods: Results: Conclusions: Access options Additional access options: Similar content being viewed by others Association between objectively measured sleep duration, adiposity and weight loss history The role of insufficient sleep and circadian misalignment in obesity Cross-sectional associations of actigraphy-assessed sleep with dietary outcomes in emerging adults References Author Contributions Funding Author information Authors and Affiliations Corresponding author Ethics declarations Conflicts of interest Rights and permissions About this article Cite this article This article is cited by The Impact of Meal Timing on Risk of Weight Gain and Development of Obesity: a Review of the Current Evidence and Opportunities for Dietary Intervention Integration of Time-Based Recommendations with CurrentPediatric Health Behavior Guidelines: Implications for Obesity Prevention and Treatment in Youth Culturally-consistent diet among individuals of Mexican descent at the US-Mexico border is associated with sleep duration and snoring The Challenge of Maintaining Metabolic Health During a Global Pandemic References
  • Article
  • Published: 28 November 2018
  • Marie-Pierre St-Onge1,2,
  • Theresa Pizinger1,
  • Kyle Kovtun1,2 &
  • …
  • Arindam RoyChoudhury3

European Journal of Clinical Nutrition volume72,pages 76–82 (2019)Cite this article

  • 1999 Accesses

  • 30 Citations

  • 7 Altmetric

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Abstract

Background:

Studies associate sleeping and eating late in the day with poor dietary quality and higher obesity risk but differences in sleep duration confound this association. We aimed to determine whether sleep and meal timing, independent of sleep duration, influenced food intake in healthy adults.

Methods:

This was a controlled, 2 × 2 inpatient crossover study with normal (0000-0800 h) or late (0330-1130 h) sleep and normal (1, 5, 11, and 12.5 h after awakening) or late (4.5, 8.5, 14.5, and 16 h after awakening) meals. Food intake was controlled while blood samples were obtained for determination of appetite-regulating hormones on days 3-4. Self-selected food intake was assessed on day 5. Data were analyzed using linear mixed model analysis with sleep, meal, and sleep x meal interaction as dependent variables.

Results:

Five participants completed all phases (mean age 25.1 ± [SD] 3.9 y, body mass index 29.2 ± 2.7 kg/m2). There was a significant sleep x meal interaction on energy intake (P = 0.035) and trends on fat and sodium intakes (P < 0.10). Overnight ghrelin concentrations were higher under normal sleep and meal conditions relative to late (P < 0.005) but lower when both were combined (P < 0.001). Overnight leptin concentrations were higher under normal meal conditions (P = 0.012). There was a significant sleep x meal interaction on ghrelin (P = 0.032) and glucagon-like peptide 1 (P = 0.041) concentrations, but not leptin (P = 0.83), in response to a test meal.

Conclusions:

Our results suggest that alignment of sleep and meals may influence food choice and energy balance. Additional research is necessary to expand and confirm our findings.

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Sleep and meal timing influence food intake and its hormonal regulation in healthy adults with overweight/obesity (1)
Sleep and meal timing influence food intake and its hormonal regulation in healthy adults with overweight/obesity (2)

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Sleep and meal timing influence food intake and its hormonal regulation in healthy adults with overweight/obesity (3)

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Sofus C. Larsen, Graham Horgan, … Berit L. Heitmann

Sleep and meal timing influence food intake and its hormonal regulation in healthy adults with overweight/obesity (4)

The role of insufficient sleep and circadian misalignment in obesity

Article 24 October 2022

Jean-Philippe Chaput, Andrew W. McHill, … Kenneth P. Wright Jr

Sleep and meal timing influence food intake and its hormonal regulation in healthy adults with overweight/obesity (5)

Cross-sectional associations of actigraphy-assessed sleep with dietary outcomes in emerging adults

Article 24 February 2024

Jessica McNeil, Nathaniel T. Berry, … Laurie Wideman

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Author Contributions

MPSO designed the study, analyzed and interpreted data, and wrote the manuscript. She takes full responsibility for the data contained in this report. TP and KK conducted the study, analyzed data, and contributed to writing the manuscript. BL provided medical supervision for the study, assisted with data interpretation and manuscript preparation. AR performed statistical analysis of the data and assisted with data interpretation and manuscript preparation.

Funding

This study was funded by the National Institutes of Health grants R56HL0119945 (MPSO) and DK26687, and also in part by Columbia University’s CTSA grant UL1 TR000040 from NCATS/NIH. This article is published as part of a supplement sponsored by the Mediterranean Diet Foundation and the Diputació de Barcelona.

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Authors and Affiliations

  1. New York Obesity Nutrition Research Center, Department of Medicine, Columbia University Medical Center, New York, NY, USA

    Marie-Pierre St-Onge,Theresa Pizinger&Kyle Kovtun

  2. Institute of Human Nutrition, Columbia University Medical Center, New York, NY, USA

    Marie-Pierre St-Onge&Kyle Kovtun

  3. Division of Biostatistics and Epidemiology, Department of Healthcare Policy and Research, Weill Cornell Medicine, Cornell University, New York, NY, USA

    Arindam RoyChoudhury

Authors

  1. Marie-Pierre St-Onge

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  2. Theresa Pizinger

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Corresponding author

Correspondence to Marie-Pierre St-Onge.

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Conflicts of interest

M-PS-O received grant support from the National Institutes of Health. ARC owns stock in Alphabet Inc and received grant support National Institutes of Health and National Science Foundation.

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Sleep and meal timing influence food intake and its hormonal regulation in healthy adults with overweight/obesity (6)

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St-Onge, MP., Pizinger, T., Kovtun, K. et al. Sleep and meal timing influence food intake and its hormonal regulation in healthy adults with overweight/obesity. Eur J Clin Nutr 72 (Suppl 1), 76–82 (2019). https://doi.org/10.1038/s41430-018-0312-x

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Sleep and meal timing influence food intake and its hormonal regulation in healthy adults with overweight/obesity (2024)

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